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Small-molecule NNMT inhibitor (5-amino-1-methylquinolinium) The pathways 5-Amino-1MQ acts on and what each one does

In some embodiments, the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

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Mire, C

The absence of marketing authorisation also means that no approved UK product information defines a human dose, indication, contraindication, adverse-effect profile or monitoring programme

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