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2-HG transport into T cells is facilitated by the sodium-dependent dicarboxylate transporter (SLC13A3), altering its effector function and cell proliferation

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Furthermore, although iron promotes cell division and growth, it can also lead to cell damage, as excessive iron accumulation can be toxic, activating cell death signaling pathways through oxidative stress (20)

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Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA

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Consistent with the reduced CoA, basal O 2 respiration was significantly decreased in lymph node T cells from Cse / mice after 7 days of cysteine deprivation, but not in those deprived of tryptophan

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