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Aberrations (increases or decreases) in either of these metabolic pathways, PPP or nucleotide synthesis, can result in the common clinical presentations of anemia, jaundice, or gout

2010;203:e16

The first time echoCG should be performed 3-6 months after the start of therapy.Then, this study should be carried out depending on the clinical assessment of the patients condition, paying particular attention to the symptoms described above at least every 6-12 months of therapy