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From the perspective of nanotherapeutic intervention, the most actionable pathological mechanisms in HD include mutant huntingtin (mHTT) expression and aggregation, selective neurodegeneration, impaired autophagy and proteasomal degradation, mitochondrial dysfunction, oxidative stress, excitotoxicity, and axonal/synaptic dysfunction (Fig

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Bacopa pairs well with nutrients like saffron, citicoline, ashwagandha, zinc, and omega-3s for enhanced cognitive and mood support