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Key regulatory axesincluding HIF-1, HHIP-PKM2, PTGES-AKT-HIF-1, and lactate/LDH-A (LDH5)-TGF-interact to collectively promote enhanced glycolysis and diminished oxidative metabolism, sustaining the pathological phenotype of the disease (8082)

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Although several sibling RBCs labelled by gata1 :dsRed were found trapped in blood clots, the vast majority of gata1 :dsRed + cells were normally circulating in blood stream both in smarca5 zko1049a and their siblings (Figure 2C)