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Discussion In summary, an efficient AuNP/oligonucleotides core/shell-type siRNA delivery nanosystem, siRNA/Ap-CS, has been developed via tiling sticky Ap-YTDB on siRNA-loaded AuNP surface to form a protective outer layer with active tumor-targeting capability, circumventing the two functional limitations: the susceptibility to enzymatic degradation in vivo and nonspecific cell permeability, encountered by emerging SNA-based delivery platforms