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Hantute-Ghesquier A, Haustrate A, Prevarskaya N

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

It can affect the polymerization of actin, the formation of stress fibers, and the proper assembly of focal adhesion complexes, which are essential for cell attachment, spreading, and directed movement

In animal models, LR3 IGF-1 was approximately 2.5-fold more potent than native IGF-1 in promoting growth, with just 44 mcg/day of LR3 producing effects equivalent to 278 mcg/day of IGF-1 (Tomas et al., 1993)

Resulting physiological effects include antimicrobial effects via FXR-induced antimicrobial peptide production (115)

Thus, this early research suggests that huperzine A is indeed capable of crossing the blood-brain barrier , meaning that it is reasonable to believe that taking it results in it actually getting to the brain (where it could have some of the cognitive effects described in the previous sections of this post)