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Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents)

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10.1038/s41585-024-00961-0 148 StowL

Evidence suggests that the mild sedative like effects of progesterone that may be important for its benefit for improving sleep quality may be in part related to key metabolites such as allopregnanolone, a metabolite produced when progesterone is taken orally

Despite similar AUD treatment rates, patients with sAH were significantly more likely to achieve early alcohol abstinence (82.2% versus 65.8%, p=0.016), and less likely to return to drinking when compared to patients with mAH (54.1% versus 72.9%