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Apoptosis was assessed using the Annexin V-FITC/PI Apoptosis Kit (cat No

Traditionally, it has been attributed to mechanical-stress-related cartilage degeneration

While GHSR is primarily active in the brain, it is also found in other tissues such as the gastrointestinal tract, heart, lungs, liver, kidneys, pancreas, fat tissue, and immune cells

Tari et al

Funding This study was funded by the National Key Research and Development Program of China (2022YFA1304201), the Beijing Natural Science Foundation (6222032), the Starting Grants Program for Young Talents at China Agricultural University, the 2115 Talent Development Program of China Agricultural University, and Chinese Universities Scientific Fund

Melatonin can exert its effects by acting through specific cellular receptors on the plasma membrane, similar to other hormones, or through receptor-independent mechanisms that involve complex molecular cross talk with other players