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Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hrbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Li C, Sun X, Li Y, Liu H, Long B, Xie D et al

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Metabolomic and lipidomic approaches have elucidated numerous circulating lipids that are directly associated with the severity of COVID-19, indicating that lipid metabolism could be a potential target for therapeutic strategies in the treatment and management of the disease ( As bioactive lipid metabolites of phosphatidylcholines (PCs), plasma lysophosphatidylcholines (LPCs) are primarily generated by the action of secretory phospholipases A2 (sPLA2) following the removal of a fatty acid ( ex vivo lung perfusion model ( Those decreased LPCs containing unsaturated acyl groups such as LPC 20:0 might impact the hosts immune or inflammatory responses by affecting the interaction with NKT cells, GCSF, and IL-6, and then lead to unfavorable outcomes

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