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Starting at lower doses and increasing gradually reduces the likelihood of systemic effects

The AuNPs obtained were applied to the in vitro BBB model to investigate the effect of nanoparticle size on BBB permeation assisted by FUS exposure (Fig

SetCys peptide 1 (1.32 mg, 0.881 mol, 1.2 equiv), cysteinyl peptide CILKEPVHGV-NH 2 (1.27 mg, 0.884 mol, 1.2 equiv) and peptide thioester 4 (1.14 mg, 0.735 mol, 1 equiv) were then successively dissolved in this solution (92 L) and the reaction mixture was stirred at 37 C

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1989 Aug;3(2):27184

The pH value of the solution formed was adjusted to 7.1 ~ 7.2 using hydrochloric acid (HCl) or NaOH and then filtered the solution