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Striatal DAT deficiency is commonly assessed by DAT PET ligands like 11 C-CFT, 18 F-CFT, 11 C-PE2I, and 11 Caltropane, as well as SPECT ligands like 123 I-Iodoflupan and 123 I- CIT, 123 I-FP-CIT, with 99100% sensitivity and specificity in identifying dopamine deficits in the early stages of PD (Palermo and Ceravolo, 2019)

Numbness in the foot or weakness when walking are also common

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