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However, it is important to recognize that NLRP3 activation and IL-1 production are not essential for the immunity-promoting action of aluminum-based vaccine adjuvants but can be considered to be a source of inflammation-related reactogenicity [40, 41]

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This distinction is crucial and defines its unique therapeutic potential

10.1021/acschembio.2c00914 568 ZhuH.HuangJ.ChenY.LiX.WenJ.TianM.et al (2022)

7f, in line with the tumor growth inhibition, the tumor sections from mice receiving treatment of BEAGA/ApoE-PDHD@ILD & R848 after LFUS irradiation presented the least tumor cells and the lowest Ki67 expression levels

Results Without active therapy, monocrotaline-rats presented a downhill course