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on the other hand, under specific metabolic stress, the abnormal activation of SLC7A11 can lead to the toxic accumulation of cystine and NADPH depletion, triggering disulfidptosis, providing a selective killing strategy for targeting tumors with high SLC7A11 expression

[DOI] [PubMed] [Google Scholar] 86.Ginsberg G, Hattis D, Sonawane B

The NAC dose (50 mg/kg/day) was selected based on previous studies demonstrating its antioxidant and cytoprotective efficacy in rodent models of heavy metal toxicity without adverse effects [19, 21, 22]

After seven rounds of dual screening, seven variants responsive to hydroxytyrosol but not the substrate and intermediates were selected

B.LannigG.BockC.SokolovaI

Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability