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Funding This study was supported by grants from the National Natural Science Foundation of China (81970504)

Subsequent mediator release not only directly and intensely affects airway inflammation, contraction of smooth muscle, and capillary permeability but also initiates release of chemotactic factors, local infiltration of activated eosinophils, and activation of T cells

Post-treatment considerations Herxheimer reactions almost always resolve on their own

SIRT1 deacetylates histones and transcription factors like p53 and NF-B to regulate gene expression

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