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Free Radic Biol Med 196:3752

Major Mechanisms of Immune Dysfunction in Autoimmunity NF-kB activation and dampening Glutathione recycling system Barrier system integrity TH-1 and TH-2 polar shifts TH-3 or regulatory T-cell activation TH-17 activation and dampening Nitric oxide isomer expressions NF-kB Activation In the last segment of this series, we learned that an increasing number of studies indicate that a protein complex known as NF-kB plays an important role in the development and progression of autoimmunity

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Endogenous FA reacts with GSH yielding HSMGSH GSH and FA metabolisms are linked as FA spontaneously reacts with GSH yielding HSMGSH (Fig