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Acute alcohol consumption disrupts redox balance and causes cellular oxidative stress, which is indicated by markers such as MDA and CYP2E1

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NFkB pathway is the major pathway of inflammation

Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression

These changes perturb the biomembranes and cause severe damage and leakage of liver markers into the circulation