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A key methodological difference must be noted here, most existing studies linking gut microbiota to ferroptosis are based on murine models that can be used to establish causality by experimental interventions such as antibiotic depletion, sterile colonization, and metabolite supplementation

Mutations are introduced into genes encoding key enzymes in C1 metabolism, most notably cystathionine beta-synthase (CBS), which converts homocysteine to cystathionine in a vitamin B6-dependent manner [2, 131]

Ween, M

The mice supplemented with leucine exhibited an upregulation in the relative abundance of Hippo-related genes, and their hepatic injury was more pronounced after APAP injection

Int J Mol Sci 18(10):2056