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Clinical Progress of Glutaminase Inhibitors Glutaminase inhibitors selectively target the overactive GLS in cancer cells, sparing GLS2 in normal cells: Blocking EMT (Epithelial-to-Mesenchymal Transition) : These inhibitors can help prevent EMT, which supports cancer spread

[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

11 AvolioE.OlivitoI.RosinaE.RomanoL.AngeloneT.De BartoloA.et al (2022)

Recently, nanomaterials possessing enzyme-like activities, termed nanozymes , have attracted considerable interest due to their advantages over their natural counterparts

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