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10.1016/j.cotox.2018.01.002 327 SmarrB

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Specific TP53 mutations impair the recruitment of 53BP1 to DNA double-strand breaks underlying the mechanism of radioresistance

However, when the cellular iron content is low, this interaction is inhibited, stabilizing NCOA4, which in turn increases ferritinophagic flux and iron release in lysosomes (78)

The most ascertain example is the use of vitamin C in the prevention and treatment of the common cold, which has been a subject of controversy for at least 70 years ( N -acetylcysteine that could avoid the rapid and detrimental loss of the intracellular content of the tripeptide during infection