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Probiotic supplementation may improve body weight, BMI, fasting glucose, insulin resistance (HOMA-IR), lipid profiles (triglycerides and very low-density lipoprotein (VLDL)-cholesterol), inflammatory markers such as C-reactive protein (CRP), and oxidative stress indicators including malondialdehyde (MDA), total antioxidant capacity (TAC), and glutathione (GSH), and hormonal parameters (total testosterone, SHBG), while also alleviating hirsutism in PCOS patients (105, 106)

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236 JurkovT.MlcekJ.SochorJ.HegedusovA

Supplements taken in non-physiological doses (i.e., amounts that exceed recommended daily amounts) are absorbed differently than physiologic doses

Acetaldehyde has been identified as a constituent in the wastes from petroleum refining, coal processing, the oxidation of alcohols, saturated hydrocarbons, or ethylene, and the hydration of acetylene (IARC, 1985)

Scientific research also shows that piperine, the active ingredient of black pepper, increases the absorption of substances that are difficult to absorb