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These findings can be backed up by Organic Acid testing for functional B2 sufficiency (see Section 2.2

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Either you dont get adequate amounts from your diet or your body is unable to fully absorb it from the food you eat

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice

1999 Apr 27;99(16):2070-2