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These cytokines, associated with activated polymorphonuclear leukocytes (PMNs) and their derived proteases, destroy newly developing tissue and degrade key growth factors

Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, et al

ROS can induce AP-1, a heterodimer composed of c-fos and c-jun, which downregulates type I collagen and upregulates MMPs in aging skin [77], and can also inhibit the TGF- signaling pathway in skin fibroblasts