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Carita A C, Eloy J O, Chorilli M, et al

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There is no doubt that the comprehensive understanding of metformins mechanism of action is crucial for its potential application in OA treatment

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In contrast to compelling preclinical evidence, clinical translation remains limited due to poor bioavailability, the absence of OC-specific clinical trials, and regulatory constraints

Americanin A induced G2/M cell cycle arrest, promoting apoptosis via ATM/ATR signaling pathways and Skp2-p27 modulation