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Insulin resistance is another critical component of PCOS pathogenesis ( Table 1 Common comorbidities associated with PCOS, its pathogenesis, and clinical aspects

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ER primarily regulates nuclear gene transcription, while ER localizes to mitochondrial membranes, modulating mitochondrial metabolism and cellular stress responses (56)

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Studies have found that levels of HGF in the vitreous fluid of PDR patients are considerably higher than in non-diabetic patients, and that the levels of HGF are especially high in the active stage of PDR (Katsura et al., 1998)