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Saffron, a spice obtained from the flowers of Crocus sativus , has been used in traditional medicine for thousands of years, with recent studies demonstrating its anti-inflammatory and immune-modulating effects

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Wohl MG, Levy HA, Szutka A, Maldia G

CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p

PMID: 27847966 | doi:10.1007/s00109-016-1488-y Seiwerth S et al

Increased metabolic rate and ATP consumption trigger mitochondrial dysfunction, consequently leading to reactive oxygen species (ROS) over-production (Tamaki et al., 2014), which is the basis of increased oxidative stress, even in the early stage of CKD