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Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial

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Mutated iPSCs and an isogeneic control were differentiated into hepatic (HPC), mesenchymal (MPC) and endothelial (EPC) progenitor cells and used to compose the liver organoids

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The primary goal was to dissect the transcriptomic dynamics of the functional modules and examine if there is a therapeutic window for drugs targeting specific pathophysiological mechanisms, such as IL-6 blockade or inhibition of NETosis

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