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Evidence that opioids may have toll-like receptor 4 and MD-2 effects

Lattante S, Sabatelli M, Bisogni G, Marangi G, Doronzio PN, Martello F, et al

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These observed advantages were correlated with notable declines in pro-inflammatory cytokines (TNF-, IL-6, IL-1) and markers of apoptosis (Bax, caspase-3, cytochrome c), in addition to a reduced incidence of TUNEL-positive cells (72)