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J Neuroimmunol 166:132143 Xiao D, Singh SV (2002) Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases

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These growth factors promote structural changes in airways such as loss of epithelial integrity, goblet-cell hyperplasia, smooth muscle hypertrophy, accumulation of fibroblasts and their differentiation into myofibroblasts, and increased angiogenesis (81)

The associated idea of genomic medicine failed to address the whole individual and outside factors that affect health, propelling the idea of epigenetics as a significant causal factor in disease development, severity and progression