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The RNA silencing experiment shows that TGR is essential for parasite survival, and the biochemical analyses indicate that TGR and its mammalian counterparts have different substrate specificities

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Although anti-seizure medications and dietary restriction of sulfur-containing amino acids may be beneficial in some cases (41), there are no treatment options for patients with mutations in the MOCS2 , GPHN (MocoD Type C), or SUOX genes

10.1038/s41598-021-00337-z 66 GoldenbergD

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Additionally, HDAC4 deacetylates transcription factors SP1 and KLF5, synergistically upregulating MKK7 transcription and activating the JNK/c-Jun pathway to drive glioma malignancy