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doi: 10.1111/j.1524-4725.2008.34314.x 65

Schlaepfer IR, Glode LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH

As additional methyl groups are introduced, the electrophilic carbon atom becomes less and less accessible to nucleophiles

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