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Excessive B12, especially in supplement form, can cause mild digestive issues in some people

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Other factors include: Underlying cause of deficiency : Pernicious anaemia, malabsorption disorders, or dietary insufficiency may affect treatment response Medication use : Metformin and proton pump inhibitors can reduce gastrointestinal B12 absorption (though this does not affect the efficacy of intramuscular injections) Individual variation : Differences in how efficiently your body utilises the injected vitamin Adherence to treatment schedule : Missing injections or delaying maintenance doses can slow recovery Discussing these factors with your healthcare provider helps set realistic expectations for your treatment journey

doi: 10.1136/gut.31.1.59 10 ReglandB.ForsmarkS.HalaouateL.MatousekM.PeilotB.ZachrissonO.et al

Different mechanisms

B12 Supports Metabolism and Energy Levels Boosting Semaglutide results with B12 helps maintain metabolic function