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Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations

Ann Intern Med 1990;113:299307

MattFCole-HunterTDonaire-GonzalezDKubeschNMartnezDCarrasco-TurigasGet al

Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients

These results suggest that gut-microbiota-derived PAMP, rather than APAP-damaged hepatocyte-derived DAMPs, may activate hepatic cDC1s owing to increased intestinal permeability in the gutliver axis in APAP-ALI mice as previously reported 58,59