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In another study, treatment with 6 mg melatonin nightly for 30 days in patients with anemia of chronic disease (ACD) resulted in significantly improved iron status and hemoglobin values

Front Cell Infect Microbiol 12:1022879

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At the transcriptional level, E2 binds to its receptor isoforms, ER and ER, to activate several nuclear-encoded mitochondrial regulatory factors, including nuclear respiratory factor 1 (NRF1) and PGC-1 (107,108)