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Here we report for the first time that prolonged stimulation of the GLP-1R for 18 hours promotes metabolic reprogramming of -cells

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Furthermore, drug(metabolite)responsive T-cell clones can be generated from responsive peripheral blood mononuclear cell cultures and characterized to define the nature of immune response (cytokine profile and cell surface markers), pathways of T-cell activation and cross-reactivity with related drug(metabolite) structures [189, 203,204,205]