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the reaction mixture was diluted with DCM (400 mL) and the organic layer was washed with water (2 500 mL), aqueous NaHCO 3 solution (500 mL) followed by standard work-up

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Heres how coffee enemas are thought to benefit the liver: Bile Duct Stimulation : Coffee, when administered rectally, is absorbed through the walls of the colon and stimulates the liver to produce bile, which is a natural detoxifier

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