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Augmenting hit identification by virtual screening techniques in small molecule drug discovery

doi: 10.1016/j.berh.2018.10.005 9 KaramiJAslaniSJamshidiAGarshasbiMMahmoudiM

(B) Anisomycin significantly inhibits the expression of ATF4

Hydration levels and healthy heart rhythm and contraction.

This two-pronged synergistic protective mechanism likely represents the core advantage distinguishing AICAR from other potential therapeutic strategies, highlighting its significant translational potential as a multi-mechanism synergistic therapeutic agent