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Intest Res 2024;22:1543.Article 5

Research indicates that IGF-1 LR3's sustained receptor activation leads to prolonged Akt phosphorylation and enhanced mTOR-mediated translation initiation in cell culture systems

Bringmann, Mller cells in the healthy and diseased retina

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However, hyperactivation of PPAR by TZD may induce adipose tissue expansion, weight gain and fatty liver in patients and animals 1,2,3 and adipogenesis in vitro 4,5