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doi: 10.4103/ijdvl.IJDVL_801_16

L., Gorlatova N., et al

Every effort was made to minimise animal suffering and reduce the number of animals used

Copper Typical signs of deficiency include: hair loss on the tip of the tail known as fishtail, crooked legs, stiff joints, diarrhea, anemia, loss of hair color (bleached out appearance), lameness, infertility or miscarriages, failure to shed their winter coat, high parasite loads, hair loss around the eyes, poor immune system, milk reduction, and even heart failure

Previous hexavalent chromium toxicity studies also found exposure to 20 M chromium (VI) to result in eryptosis, together with Ca 2+ influx, increased ROS levels, and rapid ATP consumption

doi: 10.1007/s40097-019-00325-w