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Moreover, it can endorse apoptosis by encouraging ROS production mediated through mitochondrial dysfunction, ER stress, and ER stress-mediated protein activation, including phosphorylation of eukaryotic initiation factor 2 (eIF2), protein kinase RNA-like ER kinase (PERK), CHOP, activating transcription factor 4 (ATF4), and cleaved-caspase 12, thereby inducing apoptosis

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A diverse bacterial community is capable of producing a broad spectrum of functional metabolites that exert systemic and metabolic effects on the host, thereby shaping what is recognized as the gut microbiome (8, 9)

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Yan L, Wei JA, Yang F, Wang M, Wang S, Cheng T, Liu X, Jia Y et al (2022) Physical exercise prevented stress-induced anxiety via improving brain RNA methylation