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Cell Chem Biol (2017) 24(1):8797

In addition, in the production of ROS by leukocytes, as in thyrocytes, the key enzyme is peroxidase

Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis

Disturbances in the endoplasmic reticulum can be triggered by increased oxidative stress, deposition of saturated fatty acids, hypoxia, or other stimuli, which in turn cause the accumulation of unfolded proteins in the endoplasmic reticulum lumen that is filled with proteins, antioxidants, or essential metals

This kind of protection-damage dynamic transformation can well explain the phenomenon of the bilirubin paradox in PD (Moccia et al., 2015

The docking analyses revealed that the positioning of the GSH-thiolate in relation to C-2 and O-3 of the docked substrates could enable an acidbase mechanism of dehydration or tautomerization, in which the GSH cofactor acts as a proton-relay system (Fig