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SCFAs (especially butyrate) significantly upregulate the gene expression of antimicrobial peptides, particularly -defensins (e.g., hBD-2), which constitute a critical component of the chemical barrier (97)

Further research into pharmacokinetics, pharmacodynamics and optimal delivery strategies is necessary for successful clinical application

Polymer nanoparticles, such as those made from PLGA (poly(lactic-co-glycolic acid)), offer additional benefits, including the ability to modify the surface properties to target specific receptors on the BBB [270]

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