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While the theoretical aspects of modern medicine imply the necessity to apply three principles (diagnosis, therapy, and prognosis) to tackle the burden of diseases (37, 38), many current health approaches, specifically those to manage NCDs, are based on clear-cut diagnoses that often miss the underlying causes and subtler manifestations of illness (28, 39, 40)

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The Snail gene has been found to interact with RNF20 ( E120 ubiquitin-protein ligase with monoubiquitinated H3BK2 ) and G9a (methyltransferase of H3K9me2 ) in breast cancer, and to subsequently inhibit the expression of E-cadherin

There may be other causes of color changes in the urine

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Some of the typical causes include: Viral infections: common cold, influenza, mononucleosis, and COVID-19