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The molecular mechanism and therapeutic landscape of copper and Cuproptosis in cancer

Glutathione (GSH) is represented by clear pentagons

Proc Natl Acad Sci U S A 95:14321437 Dennis PB, Pullen N, Kozma SC, Thomas G (1996) The principal rapamycin-sensitive p70(s6k) phosphorylation sites T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases