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Fragment screening at AstraZeneca: developing the next generation biophysics fragment set

Additionally, TGF- plays a role in apoptosis, ensuring the removal of damaged or unnecessary cells

PCAF-mediated acetylation of LDHB at K82 was found to significantly decrease its enzymatic activity and impair hepatic lactate clearance, resulting in lactate accumulation, which exacerbates lipid deposition and inflammatory responses by activating histone hyperacetylation in high-fat diet (HFD)-induced NAFLD