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Regulatory note: Neither peptide is FDA-approved

The Bacterial Contamination Theory proposes that such dysbiosis introduces lipopolysaccharides (LPS) into the uterine environment, which activate pattern recognition receptors through binding to the TLR4/MD2 complex, triggering MyD88-dependent signaling that phosphorylates IB and liberates NF-B for nuclear translocation, ultimately inducing chronic inflammatory cascades and further exacerbating endometriotic pathology

Consistently, they reduce DHA into ascorbate with a better efficiency ( k cat around 10 4 s 1 , k cat / K m around 10 7 M 1 .s 1 ) compared to the other enzymes ( k cat around 10 2 s 1 ) and to the reduction of glutathionylated-mercaptoethanol, the product formed upon incubation between GSH and HED ( k cat around 10 2 s 1 ) (Table 5) (Dixon et al., 2003)

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Given that MITF plays a central role in integrating environmental signals to regulate key aspects of MC identity, function, and plasticityand considering its known regulation by the MAPK/ERK pathway, which mediates ECM signal transductionwe hypothesized that MITF may serve as a key effector of ECM-dependent cues in MCs

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