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[DOI] [PMC free article] [PubMed] [Google Scholar] 396.Coates A.M., Joyner M.J., Little J.P., Jones A.M., Gibala M.J

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Moreover, there is also huge variability regarding patients age, as some etiologies, like acute viral hepatitis, are more frequent in the pediatric population and others, like DILI, are more common in elderly patients

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Decreased levels of retinoic acid in turn increase the phosphorylation of mitogen-activated protein kinases (MAPKs) and downregulate the expression of the anti-inflammatory protein mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1), which supports carcinogenesis in the lungs