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In vitro membrane-damaging experiments establish lysosomal damages caused by lysosome-associated CLN4 mutant aggregates, as a critical pathogenic linchpin in CLN4-associated neurodegeneration

Recently, cuproptosis in acute myeloid leukemia was shown to be initiated by inhibiting heme biosynthesis [53] , therefore it is conceivable that iron chelation limited heme to induce cuproptosis in the clinical trials of deferiprone

The plasmid copy number and the order of the three genes in the operon were optimized, in order to improve the hydroxytyrosol biosynthesis efficiency (Fig

Excessive alcohol and the chemicals inside these foods can strain the liver, impairing its ability to process and detox hormones effectively

Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM, OReilly SL, et al

10.1038/ng.2982 133 ShuY.SheardownS