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In individuals with heart failure, as well as in murine models of pressure overload-induced cardiac dysfunction, impaired mitochondrial oxidative energy metabolism contributes to decreased levels of long-chain acyl-coenzyme A (CoA), which accelerates cardiac remodeling and the progression of heart failure

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Applications encompass investigating cardiac repair mechanisms, ischemia-reperfusion injury prevention, and heart muscle regeneration pathways

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5Amino1MQ Peptide (NNMTi), full name 5Amino1methylquinolinium chloride, is a highly selective smallmolecule peptide inhibitor targeting NNMT