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Three to four weeks People with good absorption may still experience benefits, though many improvements linked to deficiency settle down sooner

Avoid repeated freeze-thaw cycles, which can promote disulfide rearrangement and loss of the cyclic structure

While plant foods may contain trace amounts of vitamin B12 due to contamination or fortification, they are not reliable sources for most individuals

Common but minor side effects are expected

In PB, nucleoside levels remained lower overall: ADO declined slightly and INO remained stable, likely reflecting systemic dilution or increased clearance

A patient who is subclinically deficient has the same impaired wound healing, the same elevated clotting risk, and the same anaemia vulnerability as a patient with obvious symptoms